ANTIOXIDANT, ANTI-INFLAMMATORY, AND HEP G2 CELL GROWTH-INHIBITORY EFFECTS OF AQUEOUS-ETHANOL EXTRACTS OBTAINED FROM NON-PUFFED AND COMPRESSIONAL-PUFFED SARGASSUM CRASSIFOLIUM

Authors

Cheng-Yuan Wang, Division of General Internal Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C
Tien-Chiu Wu, Division of General Internal Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C
Chien-Hui Wu, Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan, R.O.C
Yung-Hsiang Tsai, Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan, R.O.C
Shun-Min Chung, Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan, R.O.C
Yong-Han Hong, Department of Nutrition, I-Shou University (Yanchao Campus), Kaohsiung, Taiwan, R.O.C
Chun-Yung Huang, Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan, R.O.C.Follow

Abstract

There is growing interest in the bioactive components of marine algae due to their biomedical importance. In this study, a compressional-puffing (CP) process was adopted to pretreat algal samples of Sargassum crassifolium (SC), and the bioactive components of non-puffed and compressional-puffed SCs were extracted using aqueous-ethanol solution. Two extracts, namely, NPSC (non-puffed) and CPSC (compressional-puffed) were obtained, and their compositions were analyzed and compared. It was found that the composition of CPSC extract was different from that of NPSC. Further biological activity studies revealed that extracts of both NPSC and CPSC exhibited antioxidant activity, but only NPSC extract showed anti-inflammatory activity. In growth inhibition experiments, it was found that CPSC extract had a more cytotoxic effect in Hep G2 hepatoma cells and induced more DNA fragmentation of Hep G2 hepatoma cells compared with the effects exerted

Recommended Citation

Wang, Cheng-Yuan; Wu, Tien-Chiu; Wu, Chien-Hui; Tsai, Yung-Hsiang; Chung, Shun-Min; Hong, Yong-Han; and Huang, Chun-Yung (2020) "ANTIOXIDANT, ANTI-INFLAMMATORY, AND HEP G2 CELL GROWTH-INHIBITORY EFFECTS OF AQUEOUS-ETHANOL EXTRACTS OBTAINED FROM NON-PUFFED AND COMPRESSIONAL-PUFFED SARGASSUM CRASSIFOLIUM," Journal of Marine Science and Technology: Vol. 28: Iss. 3, Article 5.
DOI: 10.6119/JMST.202006_28(3).0005
Available at: https://jmstt.ntou.edu.tw/journal/vol28/iss3/5