This study examined how different processing conditions affected the antibacterial activity of epinecidin-1 alone or in combination with deionized distilled water or KY jelly and evaluated its activity against methicillin resistant Staphylococcus aureus (MRSA) in a product development pipeline. High temperature and γ-irradiation (25 kGy) decreased antimicrobial activity of epinecidin-1, as determined by measuring minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs). However, epinecidin-1 exhibited high antimicrobial activity under low pH conditions. The pH stability and the wide spectrum of action against methicillin resistant Staphylococcus aureus (MRSA) may make epinecidin-1 peptide a suitable drug candidate. This research demonstrates the effects of gamma irradiation, temperature, and pH on the antimicrobial activity of epinecidin-1 in a product development pipeline. Its stability at low pH and wide spectrum of action against MRSA make the epinecidin-1 peptide an excellent drug candidate. Epinecidin-1 is effective at repressing the growth of MRSA, and it could be used as a lead for developing new antimicrobial agents against MRSA and related organisms.
Huang, Han-Ning; Wu, Chang-Jer; and Chen, Jyh-Yih
"THE EFFECTS OF GAMMA IRRADIATION STERILIZATION, TEMPERATURE, AND PH ON THE ANTIMICROBIAL ACTIVITY OF EPINECIDIN-1,"
Journal of Marine Science and Technology: Vol. 25:
3, Article 11.
Available at: https://jmstt.ntou.edu.tw/journal/vol25/iss3/11