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Abstract

This study examined how different processing conditions affected the antibacterial activity of epinecidin-1 alone or in combination with deionized distilled water or KY jelly and evaluated its activity against methicillin resistant Staphylococcus aureus (MRSA) in a product development pipeline. High temperature and γ-irradiation (25 kGy) decreased antimicrobial activity of epinecidin-1, as determined by measuring minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs). However, epinecidin-1 exhibited high antimicrobial activity under low pH conditions. The pH stability and the wide spectrum of action against methicillin resistant Staphylococcus aureus (MRSA) may make epinecidin-1 peptide a suitable drug candidate. This research demonstrates the effects of gamma irradiation, temperature, and pH on the antimicrobial activity of epinecidin-1 in a product development pipeline. Its stability at low pH and wide spectrum of action against MRSA make the epinecidin-1 peptide an excellent drug candidate. Epinecidin-1 is effective at repressing the growth of MRSA, and it could be used as a lead for developing new antimicrobial agents against MRSA and related organisms.

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