ANTI-CANCER EFFECTS OF POLYSACCHARIDE AND PHYCOCYANIN FROM PORPHYRA YEZOENSIS

Authors

Lu-Xi Zhang, Key Laboratory of Aquatic Genetic Resources and Aquacultural Ecosystem, The Ministry of Agriculture, Shanghai Ocean University, Shanghai, P.R. China.
Chun-Er Cai, Key Laboratory of Aquatic Genetic Resources and Aquacultural Ecosystem, The Ministry of Agriculture, Shanghai Ocean University, Shanghai, P.R. China.
Ting-Ting Guo, Key Laboratory of Aquatic Genetic Resources and Aquacultural Ecosystem, The Ministry of Agriculture, Shanghai Ocean University, Shanghai, P.R. China.
Jia-Wen Gu, Key Laboratory of Aquatic Genetic Resources and Aquacultural Ecosystem, The Ministry of Agriculture, Shanghai Ocean University, Shanghai, P.R. China.
Hong-Li Xu, Key Laboratory of Aquatic Genetic Resources and Aquacultural Ecosystem, The Ministry of Agriculture, Shanghai Ocean University, Shanghai, P.R. China.
Yun Zhou, Key Laboratory of Aquatic Genetic Resources and Aquacultural Ecosystem, The Ministry of Agriculture, Shanghai Ocean University, Shanghai, P.R. China.
Yuan Wang, Key Laboratory of Aquatic Genetic Resources and Aquacultural Ecosystem, The Ministry of Agriculture, Shanghai Ocean University, Shanghai, P.R. China.
Cheng-Chu Liu, Key Laboratory of Aquatic Genetic Resources and Aquacultural Ecosystem, The Ministry of Agriculture, Shanghai Ocean University, Shanghai, P.R. China.
Pei-Min He, Key Laboratory of Aquatic Genetic Resources and Aquacultural Ecosystem, The Ministry of Agriculture, Shanghai Ocean University, Shanghai, P.R. China.Follow

Abstract

In this paper, phycocyanin and one component (PY-D2) in polysaccharide were obtained from Porphyra yezoensis to study for their potential anti-tumor effects. MTT proliferation assays showed that, at concentration of 500 mg/L for 72 h, PY-D2 treatment significantly inhibited the growth of four tumor cell lines, HO-8910, MCF-7, K562 and SMMC-7721, with the respective inhibition rates of 21.2%, 23.6%, 19.8%, and 21%. Flow cytometry analysis indicated that the anti-tumor effect of PY-D2 was associated with the cell cycle arrest at G0/G1 or G2/M check-points. Two cancer cell lines, Hep-2 and A375 were treated by different concentrations of phycocyanin, followed by radiation with He-Ne laser at the density of 20 J/cm2 and the wavelength of 632 nm. MTT assays displayed the minimal survival rate of 29.8% (Hep-2) and 16.2% (A375) at 100 μg/ml and 165 μg/ml respectively. These results suggest that both polysaccharide and phycocyanin from Porphyra yezoensis might be useful in the treatment of human cancers. These results suggest that phycocyanin and one component (PY-D2) in polysaccharide which had been obtained both from Porphyra yezoensis were potential medicaments in the treatment of some kinds of human cancers.

Recommended Citation

Zhang, Lu-Xi; Cai, Chun-Er; Guo, Ting-Ting; Gu, Jia-Wen; Xu, Hong-Li; Zhou, Yun; Wang, Yuan; Liu, Cheng-Chu; and He, Pei-Min (2011) "ANTI-CANCER EFFECTS OF POLYSACCHARIDE AND PHYCOCYANIN FROM PORPHYRA YEZOENSIS," Journal of Marine Science and Technology: Vol. 19: Iss. 4, Article 6.
DOI: 10.51400/2709-6998.2178
Available at: https://jmstt.ntou.edu.tw/journal/vol19/iss4/6